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Literature summary extracted from
- Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation (2012), Nat. Commun., 3, 877.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.66 | Mus musculus | - |
- |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.3.66 | INPP4A | - |
Mus musculus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.3.66 | malfunction | lung-specific knockdown of INPP4A by siRNA induces spontaneous inflammation in mice possibly by activating the PI3K-Akt pathway. In mice with experimental asthma, further knockdown of INPP4A by siRNA leads to a severe asthma phenotype, whereas overexpression of INPP4A reverses airway hyper-responsiveness (AHR) and airway inflammation in allergic mice | Mus musculus |
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Release 2023.1 (January 2023)
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